1 paper5 findings
Depressive episode remission
downin humans1
Depressive episode remission decreases proteomic aging acceleration in humans.
“Evidence of depressive episode remission attenuated the association between MDD and systemic and brain-specific proteomic aging acceleration.”
Humans
Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis
Aging cell4 Dec 2025
Major depressive disorder
upin silico1
Major depressive disorder increases proteomic aging acceleration in silico.
“Mendelian randomization analyses revealed a causal effect of MDD on systemic and brain-specific proteomic aging acceleration.”
In silico
Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis
Aging cell4 Dec 2025
Major depressive disorder
upin humans1
Proteomic aging acceleration raises the risk of Major depressive disorder in humans.
“Systemic and brain-specific proteomic aging acceleration were linked to higher risks of incident MDD”
Humans
Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis
Aging cell4 Dec 2025
Major depressive disorder is associated with proteomic aging acceleration in humans.
“A lifetime history of MDD was associated with accelerated proteomic aging at both systemic and organ-specific levels-including the brain-in both cohorts”
Humans
Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis
Aging cell4 Dec 2025
Mortality
upin humans1
Proteomic aging acceleration raises the risk of mortality in humans.
“Systemic and brain-specific proteomic aging acceleration were linked to higher risks of incident MDD and a greater risk of Alzheimer's disease, related dementia, and mortality among individuals with MDD in the UK Biobank.”
Humansamong individuals with MDD
Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis
Aging cell4 Dec 2025
In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.