There are 2 papers on prosaposin in aging research: 2 observational studies in people.
2 papers study it5 more mention it3 findings
“decreased amounts of PGRN and PSAP proteins were detected even in immature neurofibrillary tangles”
- Humans2
Upstream
2GRNMUTATION
no changein humans1
1 study
GRNMUTATION
no changein humans1
GRNMUTATION was not clearly linked with prosaposin in humans (frontotemporal dementia with GRN mutations).
“while PSAP signal was preserved”
Humansfrontotemporal dementia with GRN mutationsbrain
Journal of neuropathology and experimental neurology
centenarians
upin humans1
1 study
centenarians
upin humans1
centenarians are linked with higher prosaposin in humans.
“an elevation of the coenzyme Q10 binding protein Psap”
Humans
Increased oxidative stress and coenzyme Q10 deficiency in centenarians
Journal of clinical biochemistry and nutrition
Associations
1Neurofibrillary tangle development
downin humans1
1 study
Neurofibrillary tangle development
downin humans1
Neurofibrillary tangle development is associated with prosaposin in humans (immature neurofibrillary tangles).
“decreased amounts of PGRN and PSAP proteins were detected even in immature neurofibrillary tangles”
Humansimmature neurofibrillary tanglesbrain
Journal of neuropathology and experimental neurology