Pro-inflammatory SASP mediators

1. Resolvin D1 decreases pro-inflammatory SASP mediators in rat cells.

   “RvD1 treatment significantly reshaped the SASP of senescent CF, reducing pro-inflammatory mediators including IL-1β, IL-6, TNF-α, and MCP-1, while preserving anti-inflammatory cytokines.”

   CellsLPS-induced senescencecardiac fibroblast48 h

   Resolvin D1 attenuates senescence-associated secretory phenotype independently of TGF-β-driven cardiac fibroblasts differentiation to myofibroblast

   Journal of inflammation (London, England)·29 Apr 2026

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