Preservation of eight mitochondrial ribosomal protein genes' expression

Exceptional longevity is associated with preservation of eight mitochondrial ribosomal protein genes' expression in humans.

“We identify gene clusters deviating from YC-derived aging trajectories in LLIs, notably eight mitochondrial ribosomal protein genes (mRPGs) resisting typical age-related expression decline.”

HumansChinese long-lived individuals; compared with younger-control-derived aging trajectoriesn = 811

Preserved mitochondrial ribosomal protein gene expression marks a youthful transcriptional state in Chinese nonagenarians and centenarians

Cell reports. Medicine·23 Apr 2026