Premature-aging transcriptional hallmarks

1. Obesity is associated with premature-aging transcriptional hallmarks in cells.

   “At the cellular level, fibroblastic stromal cells (FSCs) selectively accumulated lipids, adopted myofibroblast-like phenotypes, and exhibited transcriptional hallmarks of premature aging.”

   Cellsobesitylung fibroblastic stromal cell

   Global matrisome changes in obese lung are linked to fibroblastic stroma and premature aging

   Cell reports·12 Sep 2025

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