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Preferential CA2 phosphorylated tau

Biomarker

1 paper3 findings

  • Humans1

Interventions

1

Football

no changein humans1

1 study

  1. Football has no effect on preferential CA2 phosphorylated tau in humans.

    “There was not a significant association between football participation and preferential CA2 p-tau.”

    Humanspostmortem cohorthippocampus CA2malesn = 174

    Postmortem tau in the CA2 region of the hippocampus in older adult men who participated in youth amateur American-style football

    Journal of Alzheimer's disease : JAD26 Jun 2025

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Associations

2

Modified CERAD score

upin humans1OR 1.48

1 study

  1. Modified CERAD score is associated with preferential CA2 phosphorylated tau in humans (OR = 1.48).

    “older age groups (odds ratio [OR] = 3.42 and 3.23) and those with greater modified CERAD scores (OR = 1.78 and 1.48) were significantly more likely to have preferential CA2 p-tau.”

    Humansmultivariate logistic regressionhippocampus CA2malesn = 174

    Postmortem tau in the CA2 region of the hippocampus in older adult men who participated in youth amateur American-style football

    Journal of Alzheimer's disease : JAD26 Jun 2025

More on Modified CERAD score

Age

upin humans1OR 3.23

1 study

  1. age is associated with preferential CA2 phosphorylated tau in humans (OR = 3.23).

    “older age groups (odds ratio [OR] = 3.42 and 3.23) and those with greater modified CERAD scores (OR = 1.78 and 1.48) were significantly more likely to have preferential CA2 p-tau.”

    Humansmultivariate logistic regressionhippocampus CA2malesn = 174

    Postmortem tau in the CA2 region of the hippocampus in older adult men who participated in youth amateur American-style football

    Journal of Alzheimer's disease : JAD26 Jun 2025

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