Frontiers in Endocrinology
Blood protein patterns linked to differing heart failure risk
A four-protein panel improved prediction beyond clinical factors and an existing blood marker, raising a measure of how well the model ranked risk by 0.021.A four-protein panel improved prediction beyond clinical factors and an existing blood marker, raising a measure of how well the model ranked risk by 0.021.
Accepted, not yet published: cohort · 42,324 peopleHeart failure
Who was studied42,324 metabolically unhealthy UK Biobank participants, median 13.65 years
What changedHeart failure risk was higher with higher protein signature levels (hazard ratio 1.93 per standard deviation) among centrally obese participants
The catchThe prediction panel lacks external validation in an independent cohort