Polysocial risk score

1. Polysocial risk score improves risk prediction model performance in silico.

   “Incorporating PSSs into models that included clinical and genetic risk factors improved predictive performance of risk prediction models (Figure 3).”

   In silicomodels including clinical and genetic risk factorsn = 20,178

   Polysocial Risk Scores and Genetic Risk Factors Are Independently and Additively Associated with Cardiometabolic Diseases Across Self-Identified Race/Ethnicity Groups

   AHA Scientific Sessions 2025 abstract·Nov 3, 2025

1. Polysocial risk score mediates biological age acceleration in humans (22.34%).

   “The BA-specific PsRS mediated the accelerated KDM-BA and PhenoAge and shorter LTL by 8.37%, 22.34% and 7.90%, respectively.”

   Humansaccelerated PhenoAge

   Association of early-life factors with biological age acceleration and the mediating effect of social environment risks in middle-aged and older adults

   Age and ageing·Nov 28, 2024

1. Polysocial risk score has no effect on mortality in humans (AUROC = 0.745 vs 0.747).

   “the most complex polysocial risk score did not demonstrate improved performance (AUROC = 0.745).”

   Humansn = 13,773

   A critique and examination of the polysocial risk score approach: predicting cognition in the Health and Retirement Study

   American journal of epidemiology·May 17, 2024

1. Polysocial risk score raises the risk of dementia in humans (aHR 1.21, 95% CI 1.15-1.26).

   “Every 1-point increase in the polysocial risk score (ranging from 0 to 10) was associated with a 21.6% higher risk (adjusted hazard ratio [aHR] = 1.21, 95% confidence intervals [95% CI] = 1.15-1.26) of developing dementia”

   Humansaverage of 6.2 yearsn = 5,199

   Social Environment, Lifestyle, and Genetic Predisposition With Dementia Risk: A Long-Term Longitudinal Study Among Older Adults

   The journals of gerontology. Series A, Biological sciences and medical sciences·May 11, 2024

2. Polysocial risk score raises the risk of dementia in humans (HR 1.19, 95% CI 1.17 to 1.21).

   “Each additional PsRS was associated with a 19% increased risk of all-cause dementia (hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.17 to 1.21)”

   Humans12.5 yearsn = 345,439

   Polysocial and Polygenic Risk Scores and All-Cause Dementia, Alzheimer's Disease, and Vascular Dementia

   The journals of gerontology. Series A, Biological sciences and medical sciences·Nov 15, 2023

More on Dementia

1. Polysocial risk score predicts cognitive impairment in humans (p = 0.04).

   “PSRS was only predictive of cognitive impairment in the Hispanic/Latino group ( p = 0.04)”

   Humansin Hispanic/Latino participants

   Social Determinants of Health and Cognitive Impairment:The Role of the Polysocial Risk Score

   AAIC 2025 abstract·Dec 23, 2025

More on Cognitive impairment

1. Polysocial risk score raises the risk of cardiometabolic disease in humans (OR 1.19–2.68 per 1 SD increase).

   “All PSSs were significantly associated with their respective CDs, independent of confounders (OR per 1 SD increase: 1.19–2.68; Figure 2-A).”

   Humansindependent of confoundersn = 20,178

   Polysocial Risk Scores and Genetic Risk Factors Are Independently and Additively Associated with Cardiometabolic Diseases Across Self-Identified Race/Ethnicity Groups

   AHA Scientific Sessions 2025 abstract·Nov 3, 2025

More on Cardiometabolic disease

1. Polysocial risk score predicts cognitive function in humans (R2 = 0.35, RMSPE = 0.858, 2.2% improvement).

   “Compared with this, the most complex polysocial risk score selected 12 predictors (R2 = 0.35 and RMSPE = 0.858; 2.2% improvement).”

   Humansn = 13,773

   A critique and examination of the polysocial risk score approach: predicting cognition in the Health and Retirement Study

   American journal of epidemiology·May 17, 2024

1. Polysocial risk score raises the risk of vascular dementia in humans (HR 1.24, 95% CI 1.19 to 1.29).

   “and a 24% increased risk of VD (1.24; 1.19 to 1.29)”

   Humans12.5 yearsn = 345,439

   Polysocial and Polygenic Risk Scores and All-Cause Dementia, Alzheimer's Disease, and Vascular Dementia

   The journals of gerontology. Series A, Biological sciences and medical sciences·Nov 15, 2023

More on Vascular dementia

1. Polysocial risk score raises the risk of Alzheimer's disease in humans (HR 1.13, 95% CI 1.10 to 1.16).

   “a 13% increased risk of AD (1.13; 1.10 to 1.16)”

   Humans12.5 yearsn = 345,439

   Polysocial and Polygenic Risk Scores and All-Cause Dementia, Alzheimer's Disease, and Vascular Dementia

   The journals of gerontology. Series A, Biological sciences and medical sciences·Nov 15, 2023

More on Alzheimer's disease