Polygenic risk score for dementia

Biomarker

2 papers1 finding

  • Humans2

Associations

1

Dementia

upin humans1HR 1.68

1 study
  1. Polygenic risk score for dementia raises the risk of dementia in humans (HR 1.68, 95% CI 1.53-1.84).

    “and 1·68, 1·53-1·84, p<0·0001, respectively”

    Humansn = 203,038

    Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study

    The lancet. Healthy longevity1 Jun 2022

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medRxiv

Dementia polygenic score links to dementia, disability, and death

Compared with favorable profiles, poor dementia polygenic profiles were associated with a 1.43 hazard ratio for a composite of dementia, disability, or death.Compared with favorable profiles, poor dementia polygenic profiles were associated with a 1.43 hazard ratio for a composite of dementia, disability, or death.

Preprint: genetic association study of 14,333 peopleDementia