Integrating polygenic risk scores, modifiable dementia risk factors, and sex as predictors of cohort membership in the Alzheimer’s and Lewy body disease spectra: A COMPASS‐ND Study

Abstract

Background: Polygenic risk scores (PRSs) summarize genetic risk across single nucleotide polymorphisms (SNPs). Alzheimer’s disease (AD) and Lewy body disease (LBD) PRSs contribute to risk detection via both multi‐mechanism (SNPs from multiple mechanistic pathways) and mechanism‐specific (SNPs from separate mechanistic pathways) versions.