Polγ K1039 hyperacetylation
2 findings
Effects
2Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
Polγ K1039 hyperacetylation induces cellular senescence in human cells.
“D257A mutation-driven hyper-acetylation of Polγ K1039 reduced human aortic smooth muscle cell (HASMC) contractility, triggering pathological hyperproliferation and mitochondrial dysfunction, collectively culminating in premature cellular senescence.”
Cellsin HASMCs
DNA Polymerase Gamma Acetylation Governs Mitochondrial Homeostasis and Vascular Cell Senescence
International journal of biological sciences4 Feb 2026
Polγ binding capacity with mtDNA
downin human cells1
1 study
Polγ binding capacity with mtDNA
downin human cells1
Polγ K1039 hyperacetylation inhibits Polγ binding capacity with mtDNA in human cells.
“hyperacetylation at K1039 disrupts Polγ's binding capacity with mtDNA.”
Cellsin HASMCs
DNA Polymerase Gamma Acetylation Governs Mitochondrial Homeostasis and Vascular Cell Senescence
International journal of biological sciences4 Feb 2026