Plasma neurofilament light

Biomarker

1 paper1 finding

  • Human trial1

Associations

1

Time-restricted feeding

downin humans1

1 study
  1. Time-restricted feeding is associated with plasma neurofilament light in humans.

    Human trialearly-stage Huntington's disease12-weekn = 20

    Effects of time-restricted eating in early-stage Huntington's disease: a pilot study

    Nature metabolism17 Sep 2026

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Alzheimer's & Dementia

Diet-related blood proteins are linked to Alzheimer's risk

Higher scores on a brain-healthy diet were associated with lower odds of Alzheimer's disease, with an odds ratio of 0.75, in 206 participants.Higher scores on a brain-healthy diet were associated with lower odds of Alzheimer's disease, with an odds ratio of 0.75, in 206 participants.

Cross-sectional study of 10,228 peopleMechanisms
Annals of Neurology

Plasma NfL rises up to 14.6 years before ALS diagnosis

In a nested case-control study, each standard deviation increase in plasma NfL was tied to 1.7-fold higher ALS odds 5 to 14.6 years before diagnosis.In a nested case-control study, each standard deviation increase in plasma NfL was tied to 1.7-fold higher ALS odds 5 to 14.6 years before diagnosis.

Case-control study of 332 peopleNfL
Science Translational Medicine

Fenofibrate improves cognition in chronic brain injury trial

In a randomized trial of 40 older adults with chronic traumatic brain injury, fenofibrate lowered plasma neurofilament light chain levels and improved cognitive function.In a randomized trial of 40 older adults with chronic traumatic brain injury, fenofibrate lowered plasma neurofilament light chain levels and improved cognitive function.

Randomised trial in 40 peopleInterventions