PiB-PET centiloid

1. Cognitive activity decreases PiB-PET centiloid in humans (interaction estimate -0.2253, 95% CI -0.4437 to -0.0070, p = 0.043).

   “Participants with higher cognitive activity experienced a less pronounced increase in PiB-PET (interaction estimate -0.2253; 95% CI -0.4437 to -0.0070; p = 0.043) and a smaller decrease in FDG-PET (interaction estimate 0.0015; 95% CI 0.0001-0.0028; p = 0.038) over time.”

   Humansdementia-free older adultsn = 1,176

   Physical and Cognitive Activities and Trajectories of AD Neuroimaging Biomarkers: Longitudinal Analysis in the Mayo Clinic Study of Aging

   Neurology·2 Dec 2025

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