Journal of Diabetes and Metabolic Disorders · Oct 27, 2026

Association of conventional and non-conventional lipid profile with cognitive impairment among type 2 diabetic patients

By Esmaeili B, Hesari E, Khalaji K et al.

PURPOSE: To explore the connection between atherogenic index of plasma, non-HDL-C, as well as conventional lipid profiles in relation to cognition dysfunction among the diabetic participants aged over 60 years. METHODS: The data of this cross-sectional research study came from the Bushehr Elderly Health (BEH) Program (Phase II) carried on the participants aged 60 and above. The functional status of the participants was assessed using the Functional Assessment Staging tool (FAST) and Category Fluency Test (CFT). After the measurement of lipid parameters, we used multiple logistic regression to analyze their relationship with cognitive impairment (CI) among the participants. RESULTS: There were 836 participants in this cross-sectional study. Of them, 339 had cognitive decline. The average age of the subjects was 68.6 ± 5.7 years. There was no relationship between lipid parameters and cognition dysfunction with the exception of HDL-C. A higher amount of HDL-C had a protective role. While older age (OR = 1.05, 95% CI = 1.01-1.08, P = 0.002) and higher education (OR = 1.08, 95% CI = 1.04-1.12, P < 0.001) were positively related to cognitive impairment, male gender (OR = 0.41, 95% CI = 0.27-0.62, P < 0.001) was associated with 59% reduced odds of cognition impairment. CONCLUSION: Among conventional lipid profiles, only the HDL-C levels were related to cognitive dysfunction and no relationship was observed between cognitive impairment and non-conventional lipids.

doi.org/10.1007/s40200-026-02116-xPubMed 42947927Populations