Aging Cell
Protein loss weakened barriers in human brain vessel cells
In lab experiments, reducing alpha-synuclein, a protein, made layers of human brain blood-vessel cells leakier; suppressing an enzyme returned leakage to normal.In lab experiments, reducing alpha-synuclein, a protein, made layers of human brain blood-vessel cells leakier; suppressing an enzyme returned leakage to normal.
Human cell studyMechanisms
Who was studiedHuman brain microvascular endothelial cells, 48 h
What changedBrain vessel cell layers became leakier after SNCA protein depletion than control cell layers
The catchOff-target siRNA effects and transfection stress could contribute to barrier damage