P16HIGH cells
3 papers study it5 more mention it3 findings
- Animals2
Upstream
1Older age
upin mice1
1 study
Older age
upin mice1
Older age increases P16HIGH cells in mice.
“We found tdTomato-positive p16high cells detectable in all organs, which were enriched with age.”
Animalsall organs
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo
Cell metabolism
Associations
2Inflammation
upin mice1
1 study
Inflammation
upin mice1
P16HIGH cells are associated with inflammation in mice.
“Bulk RNAseq indicated that genes expressed by p16High cells were associated with inflammation and phagocytosis”
Animalscentral nervous system
Identification of distinct and age-dependent p16High microglia subtypes
Aging cell
Older age
upin mice1
1 study
Older age
upin mice1
P16HIGH cells are associated with older age in mice.
“we show that the number of p16High cells is significantly increased in the central nervous system (CNS) of 2-year-old mice”
Animalscentral nervous system
Identification of distinct and age-dependent p16High microglia subtypes
Aging cell
Latest
2 papers in 12 monthsMolecules and Cells
The role of p21 in cellular senescence and aging-related diseases
ReviewCellular senescence
Aging Cell
Identification of distinct and age-dependent p16High microglia subtypes
Experiments in miceMechanisms
Cell Metabolism
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo
Experiments in miceCDKN2A
Nature Cell Biology
p16High senescence restricts cellular plasticity during somatic cell reprogramming
Experiments in mouse cellsEpigenetic regulation of gene expression
Cell Metabolism
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan
Experiments in miceCellular senescence