Oxidized LDL

1. Glibenclamide increases oxidized LDL in humans (242.4 to 470.7 ng/mL).

   “ox-LDL (242.4 [180.9] ng/mL to 470.7 [247.3] ng/mL; P = 0.004) and urinary excretion of 8-iso PGF(2α) (121.6 [39.6] pmol/mmol creatinine to 152.5 [41.8] pmol/mmol creatinine; P = 0.03) increased significantly.”

   Human trialin T2DM patients inadequately controlled by metformin16 weeks

   Effects of acarbose versus glibenclamide on glycemic excursion and oxidative stress in type 2 diabetic patients inadequately controlled by metformin: a 24-week, randomized, open-label, parallel-group comparison

   Clinical therapeutics·10 Nov 2011

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