Osteoclast-derived small extracellular vesicles

1. Plasma is associated with osteoclast-derived small extracellular vesicles in humans.

   “these preliminary findings demonstrate feasibility of sEV-Osteoclast isolation from plasma.”

   Humansn = 11

   Osteoclast-derived small extracellular vesicle as novel liquid biopsy for assessing bone health in older adults

   GSA 2025 abstract·31 Dec 2025

1. Osteoclast surface markers are associated with osteoclast-derived small extracellular vesicles in humans (6.70±0.80% TRAP+, 2.54±0.27% RANK+, 7.36±0.64% CD51+, 3.63±0.27% DCStamp+).

   “revealing that 6.70±0.80% of plasma-total sEV were TRAP positive (+), 2.54±0.27% were RANK+, 7.36±0.64% were CD51+, and 3.63±0.27% were DCStamp+.”

   Humansn = 11

   Osteoclast-derived small extracellular vesicle as novel liquid biopsy for assessing bone health in older adults

   GSA 2025 abstract·31 Dec 2025

More on Osteoclast surface markers