Optic nerve head FDG uptake

1. Rapamycin increases optic nerve head FDG uptake in humans.

   “left retinal ganglion cell layer thickness (p=0.044), and optic nerve head [ 18 F]FDG uptake (p=0.040).”

   Human trialEarly-stage Alzheimer's disease; uncontrolled pre-post comparisonoptic nerve head7 mg once weekly26 weeks

   Multi-modal and multi-organ in vivo imaging to assess geroprotective interventions in humans: results from a pilot trial of rapamycin in Alzheimer’s Disease

   medRxiv·12 Mar 2026Preprint

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