Older-age-associated DNA methylation pattern

1. Caloric restriction increases older-age-associated DNA methylation pattern in humans.

   “CR altered DNAm at chronological-age associated CpG sites in the direction of older age (p<0.003 at 12- and 24-month follow-ups).”

   Human trialsecondary analyses of chronological-age-associated CpG siteswhole blood12% average calorie restriction12 and 24 monthsn = 197

   Epigenome-wide association study analysis of calorie restriction in humans, CALERIE™ Trial analysis

   bioRxiv (Cold Spring Harbor Laboratory)·Jun 5, 2022Preprint

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