BMI- and smoking-associated DNA methylation patterns

1. Caloric restriction is associated with BMI- and smoking-associated DNA methylation patterns in humans (Changes opposite to BMI- and smoking-associated patterns).

   “CR induced DNAm changes opposite those associated with body mass index (BMI) and smoking (p<0.003 at 12- and 24-month follow-ups).”

   Human trialsecondary analyses of CpG sites identified in published EWASwhole blood12% average calorie restriction12 and 24 monthsn = 197

   Epigenome-wide association study analysis of calorie restriction in humans, CALERIE™ Trial analysis

   bioRxiv (Cold Spring Harbor Laboratory)·Jun 5, 2022Preprint

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