Nuclear accumulation of YAP1

Loss of nuclear-cytoplasmic compartmentalization is associated with nuclear accumulation of YAP1 in cells.

“Loss of compartmentalization is accompanied by mitochondrial dysfunction, increased reactive oxygen species production, and aberrant nuclear accumulation of YAP1”

Cellsaging podocytespodocyte

Loss of nuclear-cytoplasmic compartmentalization is a hallmark of aging in podocytes

bioRxiv (Cold Spring Harbor Laboratory)·1 May 2026Preprint