NRK, PDK4, AQP1, and LMO2 expression

Older donor age is associated with NRK, PDK4, AQP1, and LMO2 expression in human cells (NRK downregulated; PDK4, AQP1, and LMO2 upregulated).

“RNA sequencing identified 9 age-associated genes, with validated downregulation of NRK and upregulation of PDK4, AQP1, and LMO2 in OA CD146+ BMSC.”

CellsOlder-adult-derived versus middle-aged-derived cellsCD146+ bone marrow stromal celln = 29

Impact of aging on CD146⁺ mesenchymal stromal cells-mediated regulation of bone marrow CD34⁺ hematopoietic stem/progenitor cell mobilization

Frontiers in bioengineering and biotechnology·7 May 2026