Myeloid cells
Biomarker1 paper
- Humans1
Funding
National Institute on AgingUS$1.2m2 grants since 2024
The role of mutant Lamin A in myeloid cells in Hutchinson-Gilford progeria syndrome
National Institute on AgingVanderbilt University Medical CenterUS$481k2026–2028
Targeting brain myeloid cells with siRNA-lipid conjugates for treatment of Alzheimer's disease
National Institute on AgingVanderbilt UniversityUS$761.4k2024–2029
Latest
24Older mice had delayed immune responses and recovery from flu
An experiment spanning 16 combinations of age, sex and infection stage also found persistent inflammatory responses in older male mice at later…An experiment spanning 16 combinations of age, sex and infection stage also found persistent inflammatory responses in older male mice at later stages.
Fungus drives spleen aging in mice, eased by astragaloside IV
In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune…In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron homeostasis.
DNMT3A mutations enhance macrophage migration in cells
Using human stem cell-derived macrophages, a preprint finds DNMT3A mutations derepress bivalent Polycomb target genes and enhance cell migration…Using human stem cell-derived macrophages, a preprint finds DNMT3A mutations derepress bivalent Polycomb target genes and enhance cell migration toward injured tissue.