Mutational patterns

2 papers

Cells2

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9 in 12 months

CellOct 16

DNA methods appear complementary in human cells and tissues

Benchmarks using human cell lines and donor tissues produced data for nine samples and suggested that three DNA analysis approaches offer complementary information.Benchmarks using human cell lines and donor tissues produced data for nine samples and suggested that three DNA analysis approaches offer complementary information.

Study of 9 peopleAI & data

Paper

HemaSphereOct 7

Blood-cell mutation patterns linked to cancer progression

A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.

Cohort study of 256 peopleBiomarkers

Paper

bioRxivOct 2

Human neurons accumulate far more mutations over lifespan than shorter-lived mammals

Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.

Preprint: study in peopleMechanisms

Paper

NeuronAug 11