1 paper1 finding
Platinum-based drugs
upin humans1
Platinum-based drugs induce mutations in humans.
“Platinum-based drugs cause mutations and liver aging in children treated for cancer.”
Reviewin children treated for cancerliver
Platinum chemotherapy ages the liver
Science (New York, N.Y.)10 Sep 2026
National Institute on AgingUS$33.4mNational Cancer InstituteUS$12.4mNational Institute of Neurological Disorders and StrokeUS$16.6m
Food and Drug AdministrationStanford UniversityUS$648k2026–2030
Patterns and Mechanisms Underlying Somatic Mutations Across Long-Lived Bats
National Institute on AgingPennsylvania State University, theUS$249k2024–2028
Resolving the cancer relevance of predisposition gene mutations
National Cancer InstituteMayo Clinic RochesterUS$893k2020–2027
Impact of Cancer Therapy on Sperm Mutations Using Sequential Samples
National Institute of Child Health and Human DevelopmentCase Western Reserve UniversityUS$674k2026–2031
Developing Mutation Signature Extraction (MSE) for human tissues
National Cancer InstituteDuke UniversityUS$232.3k2026–2029
Causes and Effects of Somatic Mutation in Parkinson’s disease
National Institute on AgingUniv of Massachusetts Med Sch WorcesterUS$693.8k2026–2031
National Institute on AgingHarvard Medical SchoolUS$125.9k2026–2028
National Cancer InstituteMayo Clinic RochesterUS$421.7k2023–2028
Understanding mitochondrial mutations that drive human tissue aging
National Institute on AgingUniversity of California Los AngelesUS$173.8k2024–2029
Spatial single-cell analysis of somatic mutation in human brain during aging and neurodegeneration
National Institute on AgingUniv of Massachusetts Med Sch WorcesterUS$1m2023–2028
The method paired gene activity and DNA-marking measurements at about 10,000 cells per sequencing library, a collection of prepared genetic material.The method paired gene activity and DNA-marking measurements at about 10,000 cells per sequencing library, a collection of prepared genetic material.
Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.
In an analysis of 889,215 people, clonal blood mutations were associated with serious bacterial infections, with a hazard ratio of 1.22.In an analysis of 889,215 people, clonal blood mutations were associated with serious bacterial infections, with a hazard ratio of 1.22.
Experiments with three-layer vessels built from human cells found that support cells increased several vascular disease features in a model of Hutchinson-Gilford progeria…Experiments with three-layer vessels built from human cells found that support cells increased several vascular disease features in a model of Hutchinson-Gilford progeria syndrome.
A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.