Muscle oxygen consumption

1. NNT increases muscle oxygen consumption in mice.

   “the rates of oxygen consumption did decrease in the soleus and vastus lateralis muscles of middle-aged and older Nnt-/- mice.”

   Animalsshown by Nnt knockout compared with age-matched Nnt+/+ controlssoleus and vastus lateralis muscles

   Aging-dependent mitochondrial bioenergetic impairment in the skeletal muscle of NNT-deficient mice

   Experimental gerontology·25 May 2024

More on NNT

1. Adipose tissue thickness predicts muscle oxygen consumption in humans (explaining 53.9% of the variance).

   “adipose tissue thickness (ATT) was the strongest predictor of leg mVO2, explaining 53.9% of the variance.”

   Humansleg muscle

   Muscle oxygen consumption and microvascular function in healthy aging assessed by near-infrared spectroscopy: effect of adipose tissue thickness and physical fitness

   Frontiers in physiology·5 Dec 2025

More on Adipose tissue thickness

1. age predicts muscle oxygen consumption in humans (explaining 20.3% of the variance).

   “revealed age as a moderate predictor of forearm mVO2, explaining 20.3% of the variance”

   Humansforearm muscle

   Muscle oxygen consumption and microvascular function in healthy aging assessed by near-infrared spectroscopy: effect of adipose tissue thickness and physical fitness

   Frontiers in physiology·5 Dec 2025