Modified mitochondrial local constraint score sum

Modified mitochondrial local constraint score sum is associated with processing speed in humans (β=-4.94 points, 95% CI: -9.44, -0.43).

“Participants with mMSS > 0.5 had significantly worse processing speed at baseline compared to those with mMSS= 0”

HumansDiabetes; mMSS > 0.5 versus mMSS = 0; adjusted analysisbaseline52.1% femalesn = 954

Association of mitochondrial copy number and heteroplasmy with cognitive function in the ACCORD trial

Neurobiology of aging·11 Oct 2026