There are 10 papers on miR-181a in aging research: 5 observational studies in people, 3 in animals, 2 reviews.
10 papers study it15 more mention it3 findings
“significantly correlated with worsened blood parameters of inflammation (such as low levels of albumin and bilirubin and high lymphocyte content)”
- Humans5
- Animals3
Interventions
1Caloric restriction
upin rats1
1 study
Caloric restriction
upin rats1
Caloric restriction increases miR-181a in rats.
“CR downregulated the proinflammatory miR-19b and increased the anti-inflammatory miR-181a and its known targets.”
AnimalsAIN93M with 75% of energy requirementskeletal muscle75% of energy requirementsix monthsmales
The Journal of nutritional biochemistry
Associations
2Multimorbidity
upin humans1
1 study
Multimorbidity
upin humans1
miR-181a is associated with multimorbidity in humans.
“miR-181a positively correlated with the overall multimorbidity burden, measured by CIRS Comorbidity Score, in both genders”
Humansplasman = 244
BMC geriatrics
Inflammation
upin humans1
1 study
Inflammation
upin humans1
miR-181a is associated with inflammation in humans (particularly in females).
“significantly correlated with worsened blood parameters of inflammation (such as low levels of albumin and bilirubin and high lymphocyte content)”
Humansparticularly in femalesplasman = 244
BMC geriatrics
Latest
International Journal of Molecular Sciences
Molecular Biomarkers and Therapeutic Approach of Patients with Diabetes and Obstructive Sleep Apnea
ReviewObstructive sleep apnea
Frontiers in Cardiovascular Medicine
Circulating miR-29b decrease in response to sarcopenia in patients with cardiovascular risk factors in older Chinese
Cohort study of 93 peopleSarcopenia
BMC Geriatrics
Circulating miR-181a as a novel potential plasma biomarker for multimorbidity burden in the older population
Cohort study of 244 peopleMultimorbidity
Global Heart
Circulating MicroRNAs as Biomarkers of Accelerated Sarcopenia in Chronic Heart Failure
Case-control study in peopleChronic heart failure
Immunity & Ageing
miR-181a-regulated pathways in T-cell differentiation and aging
ReviewBlood and immune system
The Journal of Clinical Investigation
Histone deficiency and accelerated replication stress in T cell aging
Experiments in miceBlood and immune system
The Journal of Nutritional Biochemistry
Caloric restriction following early-life high fat-diet feeding represses skeletal muscle TNF in male rats
Experiments in ratsDietary restriction
BioMed Research International
Age-Related Immune Profile of the T Cell Receptor Repertoire, Thymic Recent Output Function, and miRNAs
Cross-sectional study in peopleImmune response