Aging Cell
Mitochondrial DNA and age shape retinal changes in mice
Experiments in mice with matching nuclear DNA but different mitochondrial DNA linked aging to changes in retinal energy-producing proteins and immune signaling.Experiments in mice with matching nuclear DNA but different mitochondrial DNA linked aging to changes in retinal energy-producing proteins and immune signaling.
Mouse studyMitochondrion
Who was studiedMice with matched nuclei and different mtDNA, against same-age mice with C57 mtDNA
What changedRetinal mitochondrial DNA damage was lower in mice with C3H mtDNA than C57 mtDNA at 20 months
The catchOnly 3–4 animals per group limited power to detect age-by-genotype interactions