AgingResearch.NewsJoin free

Loss of X chromosome

There are 3 papers on loss of X chromosome in aging research: 2 observational studies in people, 1 review. The newest story, Nov 9, 2026: “Chromosome changes linked to differing clot risks in people”.

Biomarker

3 papers study it4 findings

2 new papers in 30 daysSee all 3 papers on loss of X chromosome

“LOX and large LOX were not significantly associated with VTE.”
Association of Mosaic Chromosomal Alterations with Incident Venous Thromboembolic Disease in 450,000 IndividualsAHA Scientific Sessions 2026 abstract2026doi:10.1161/circ.154.suppl_1.7624
  • Humans2

Effects

2

Venous thromboembolism

no changein humans1

1 study

  1. Loss of X chromosome was not clearly linked with venous thromboembolism in humans (Both overall and large clones (clonal fraction ≥10%)).

    “LOX and large LOX were not significantly associated with VTE.”

    HumansBoth overall and large clones (clonal fraction ≥10%)

    Chromosome changes linked to differing clot risks in people

    AHA Scientific Sessions 2026 abstract

More on Venous thromboembolism

Cellular function

downin humans1

1 study

  1. Loss of X chromosome impairs cellular function in humans.

    “LOX impairs cellular functions”

    Reviewfemales

    Genome Aging in Women: Hematopoietic Loss of X Chromosome as An Exemplar

    Aging cell

Associations

2

Hematological malignancy

upin humans1

1 study

  1. Loss of X chromosome is associated with hematological malignancy in humans.

    “LOX impairs cellular functions and is strongly linked to hematological malignancies and a range of benign diseases.”

    Reviewfemales

    Genome Aging in Women: Hematopoietic Loss of X Chromosome as An Exemplar

    Aging cell

More on Hematological malignancy

Biological age

upin humans1

1 study

  1. Biological age is associated with loss of X chromosome in humans.

    “The age-dependent loss of the X chromosome in female blood is also identified, a finding that has been challenging with existing methods.”

    Humansbloodfemales

    A Novel Method for Acquired Sex Chromosome Mosaicism

    Advanced biology

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 12 papers in 12 months
AHA Scientific Sessions 2026 Abstract

Chromosome changes linked to differing clot risks in people

Large non-sex chromosome changes were linked to higher clot risk than in noncarriers, with a hazard ratio (relative risk over time) of 1.29.Large non-sex chromosome changes were linked to higher clot risk than in noncarriers, with a hazard ratio (relative risk over time) of 1.29.

Cohort studyPopulations
Paper

Related