Loss of Y chromosome

2 papers3 findings

Humans1

Effects

1

Tumor evolution

upin humans1

1 study

Loss of Y chromosome increases tumor evolution in humans.
Reviewsynergistic interaction between two types of LOY cells
On the role of Y chromosome loss in malignancies: the driving mechanisms and potentials in precision oncology
Yi chuan = Hereditas1 Aug 2026

Upstream

1

Neoplasm

upin humans1

1 study

Neoplasm increases loss of Y chromosome in humans.
Humansin different organsmales
Human Y chromosome pan-organ mapping reveals progressive mosaic loss from normal to cancer
JCI insight8 Sep 2026

More on Neoplasm

Associations

1

Tumor susceptibility

upin humans1

1 study

Loss of Y chromosome is associated with tumor susceptibility in humans.
Reviewin peripheral blood immune cellsmales
On the role of Y chromosome loss in malignancies: the driving mechanisms and potentials in precision oncology
Yi chuan = Hereditas1 Aug 2026

Funding

2 grants since 2024

National Institute on AgingUS$186.4kNational Cancer InstituteUS$129.1k

Latest

4 in 12 months

Frontiers in Immunology16 Sep

Age and sex: dual drivers remodeling the anti-tumor immune microenvironment and shaping personalized immuno-oncology

ReviewBlood and immune system

JCI Insight8 Sep

Human Y chromosome pan-organ mapping reveals progressive mosaic loss from normal to cancer

Cohort study of 405 peopleBiomarkers

Yi Chuan17 Aug

On the role of Y chromosome loss in malignancies: the driving mechanisms and potentials in precision oncology

ReviewMechanisms

JACC Advances9 Aug

Mosaic Loss of Y Chromosome and Risks of Peripheral Arterial and Aortic Diseases

Cohort study of 216,086 peoplePeripheral arterial disease