Longevity Relatives Count score

1. Longevity Relatives Count score is associated with 9-HOTrE/alpha-linolenic acid ratio in humans.

   “Lipid mediators, including elevated 6-keto-PGF1a and reduced 9-HOTrE/alpha-linolenic acid ratio, reflected preserved endothelial homeostasis and attenuated inflammatory signaling.”

   Humansfamilial longevityplasman = 495

   Multi-omics integration identifies metabolic and inflammatory pathways underlying familial longevity

   medRxiv·15 May 2026Preprint

More on 9-HOTrE/alpha-linolenic acid ratio

1. Longevity Relatives Count score is associated with 6-keto-PGF1α in humans.

   “Lipid mediators, including elevated 6-keto-PGF1a and reduced 9-HOTrE/alpha-linolenic acid ratio, reflected preserved endothelial homeostasis and attenuated inflammatory signaling.”

   Humansfamilial longevityplasman = 495

   Multi-omics integration identifies metabolic and inflammatory pathways underlying familial longevity

   medRxiv·15 May 2026Preprint

More on 6-keto-PGF1α

1. Longevity Relatives Count score is associated with plasma amino acid derivatives and nucleosides in humans.

   “High LRC scoring individuals exhibited lower levels of amino acid derivatives (prolylhydroxyproline, 5-hydroxy-tryptophan, asymmetric dimethylarginine), nucleosides (2-methylguanosine, 7-methylguanosine, pseudouridine)”

   Humansfamilial longevityplasman = 495

   Multi-omics integration identifies metabolic and inflammatory pathways underlying familial longevity

   medRxiv·15 May 2026Preprint

More on Plasma amino acid derivatives and nucleosides