3 papers4 findings
Older age
upin humans2
Older age increases locus coeruleus intensity in humans.
“LC intensity was significantly higher in older compared to young adults”
Humanslocus coeruleus
AAIC 2025 abstract7 Jan 2026
Older age increases locus coeruleus intensity in humans.
“LC intensity was significantly higher in older compared to young adults”
Humans
AAIC 2025 abstract23 Dec 2025
Cognitive function
mixedin humans1
Locus coeruleus intensity is associated with cognitive function in humans.
“significant relationships were found in the left LC intensity and language and the right LC intensity and working memory only among young adults”
Humansbrain
AAIC 2025 abstract23 Dec 2025
Regional neural activity
downin humans1
Locus coeruleus intensity is associated with regional neural activity in humans.
“higher LC intensity was related to lower regional brain activity in widespread brain regions including the dorsomedial prefrontal cortex and the cerebellum”
Humansacross all cognitively normal adultsbrain
AAIC 2025 abstract23 Dec 2025
Each standard deviation decrease in locus coeruleus intensity was associated with 53% higher odds of testing positive for an Alzheimer's blood marker.Each standard deviation decrease in locus coeruleus intensity was associated with 53% higher odds of testing positive for an Alzheimer's blood marker.