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Lipid polarity

Biomarker

1 paper2 findings

  • Cells1

Upstream

1

3xTg-AD genotype

downin mouse cells1

1 study

  1. 3xTg-AD genotype decreases lipid polarity in mouse cells.

    “AD-like (or 3xTg-AD) neurons fail to show this age-related increase in lipid polarity, instead displaying a consistent reduction in lipid polarity across all ages.”

    Cells3xTg-AD neurons compared with non-transgenic neuronshippocampal neurons

    AD-genes and Aging Increase Count and Size of Lipid Droplets, Accompanied by Accumulation of Neutral Lipids Across Compartments in Hippocampal Neurons

    bioRxiv (Cold Spring Harbor Laboratory)5 Jul 2025Preprint

Associations

1

Age

mixedin mouse cells1

1 study

  1. age is associated with lipid polarity in mouse cells.

    “NTg neurons exhibit a progressive increase in global lipid polarity from young to middle age, followed by a slight decrease in old age.”

    Cellsnon-transgenic micehippocampal neurons

    AD-genes and Aging Increase Count and Size of Lipid Droplets, Accompanied by Accumulation of Neutral Lipids Across Compartments in Hippocampal Neurons

    bioRxiv (Cold Spring Harbor Laboratory)5 Jul 2025Preprint

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