LINE1 DNA copy number

1. APP/PS1 decreases LINE1 DNA copy number in mice.

   “Compared to age-matched wild-types, APP/PS1 mice constantly have significantly decreased L1 content but increased L1 expression”

   Animalscompared to age-matched wild-typesbrain

   Unveiling Aging and Alzheimer's Disease-Associated Dynamics of LINE1 DNA Content and Protein Expression in Mouse Brains

   Aging cell·17 Nov 2025

More on APP/PS1