L1 ORF1 and ORF2 protein expression

1. APP/PS1 increases L1 ORF1 and ORF2 protein expression in mice.

   “Compared to age-matched wild-types, APP/PS1 mice constantly have significantly decreased L1 content but increased L1 expression”

   Animalscompared to age-matched wild-typesbrain

   Unveiling Aging and Alzheimer's Disease-Associated Dynamics of LINE1 DNA Content and Protein Expression in Mouse Brains

   Aging cell·17 Nov 2025

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