Left ventricular late gadolinium enhancement

1. Left ventricular late gadolinium enhancement is associated with major adverse cardiovascular events in humans (HR 2.5, 95% CI 1.2–5.2).

   “LGE presence was associated with greater major adverse cardiovascular event rates (hazard ratio, 2.5 [95% CI, 1.2-5.2]).”

   Humans54% malesn = 472

   Blood pressure history linked to signs of heart scarring

   Hypertension (Dallas, Tex. : 1979)·Oct 19, 2026

1. Systolic blood pressure trajectory steepness is associated with left ventricular late gadolinium enhancement in humans (6% to 12% greater LGE per 1 mm Hg/y steeper SBP rise).

   “Each 1 mm Hg/y steeper SBP rise during age intervals 36 to 43, 43 to 53, and 53 to 63 was associated with 6% to 12% greater LGE”

   HumansLGE calculated using the 3-SD methodleft ventricleeach 1 mm Hg/y steeper systolic blood pressure rise54% malesn = 472

   Blood pressure history linked to signs of heart scarring

   Hypertension (Dallas, Tex. : 1979)·Oct 19, 2026

More on Systolic blood pressure trajectory steepness

1. Cumulative systolic blood pressure burden is associated with left ventricular late gadolinium enhancement in humans (16% to 24% greater LGE per 10 mm Hg sustained greater SBP).

   “each 10 mm Hg sustained greater SBPs on any age interval from 36 to 69 associated with 16% to 24% greater LGE”

   HumansIndependent of systolic blood pressure at 77 years; LGE calculated using the 3-SD methodleft ventricleeach 10 mm Hg sustained greater systolic blood pressure54% malesn = 472

   Blood pressure history linked to signs of heart scarring

   Hypertension (Dallas, Tex. : 1979)·Oct 19, 2026

More on Cumulative systolic blood pressure burden

1. Systolic blood pressure is associated with left ventricular late gadolinium enhancement in humans (6% to 11% greater LGE per 10 mm Hg greater SBP).

   “each 10 mm Hg greater individual SBPs at 36 to 69 years were associated with 6% to 11% greater LV LGE”

   HumansLGE calculated using the 3-SD methodleft ventricleeach 10 mm Hg greater systolic blood pressure54% malesn = 472

   Blood pressure history linked to signs of heart scarring

   Hypertension (Dallas, Tex. : 1979)·Oct 19, 2026

More on Systolic blood pressure