1 paper2 findings
HOMA-IR
mediatesin humans1
HOMA-IR mediates Klemera-Doubal method age in humans (21.67% in males vs 12.71% in females).
“HOMA-IR partially mediated VAI-BA associations, with a greater percentage in males than in females in both VAI-KDMAge (21.67% vs. 12.71%)”
Humansmediating VAI-KDMAge association
PloS one29 Sep 2025
Visceral adiposity index
upin humans1
Visceral adiposity index increases Klemera-Doubal method age in humans (β = 1.02 (95% CI: 0.81-1.23)).
“females showed stronger associations than males for each 1-unit VAI increase with KDMAge elevation (βfemale = 1.02, 95% CI: 0.81-1.23”
Humansfemales
PloS one29 Sep 2025
Blood metabolic profiles statistically accounted for 81.14% of the link with one biological age measure, compared with 19.92% for another and 32.27% for frailty.Blood metabolic profiles statistically accounted for 81.14% of the link with one biological age measure, compared with 19.92% for another and 32.27% for frailty.