Keratin 8 serine 73 phosphorylation

Biomarker

1 paper1 finding

Animals1

Upstream

p38 MAPK signalling

upin cells1

1 study

p38 MAPK signalling increases keratin 8 serine 73 phosphorylation in cells.
“In vitro, pharmacological inhibition of p38 reduced p-K8 S73 levels, suppressed MDB formation, and attenuated the senescent phenotype.”
Cellsshown by pharmacological inhibition of p38 in an MDB-forming hepatocyte modelhepatocyte
A pathway may link liver protein clumps and senescence in mice
Archives of gerontology and geriatrics1 Oct 2026

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Archives of Gerontology and Geriatrics15 min

A pathway may link liver protein clumps and senescence in mice

Experiments in two mouse models of liver disease found protein clumps alongside signs of senescence, a state in which cells stop dividing.Experiments in two mouse models of liver disease found protein clumps alongside signs of senescence, a state in which cells stop dividing.

Experiments in miceCellular senescence

Paper

Keratin 8 serine 73 phosphorylation

Upstream

Latest

A pathway may link liver protein clumps and senescence in mice

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