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KDM2-based delta age

Biomarker

1 paper3 findings

  • Humans1

Effects

1

Cardiovascular disease mortality prediction

upin humans1

1 study

  1. KDM2-based delta age improves cardiovascular disease mortality prediction in humans (YCS: NRI 7.9%, IDI 0.4%; JCS: NRI 9.1%, IDI 0.7%; P < 0.001).

    “Incorporating KDM2-based DA into the traditional risk factors model significantly improved the prediction of CVD death”

    HumansAdded to the traditional risk factors model in Yixing and Jurong cohorts

    Association and predictive values of nine biological age measures for cardiovascular disease mortality: screening and validation from two prospective cohort studies

    GeroScience13 Sep 2025

Associations

2

Mortality

upin humans1HR 1.089

1 study

  1. KDM2-based delta age is associated with mortality in humans (HR 1.089, 95% CI 1.050–1.129).

    “and all-cause death (YCS: HR(95% CI) = 1.203(1.075-1.346); JCS: HR(95% CI) = 1.089 (1.050-1.129); P < 0.05).”

    HumansExternal validation in the Jurong Cohort Studyn = 16,652

    Association and predictive values of nine biological age measures for cardiovascular disease mortality: screening and validation from two prospective cohort studies

    GeroScience13 Sep 2025

Cardiovascular disease mortality

upin humans1HR 1.167

1 study

  1. KDM2-based delta age is associated with cardiovascular disease mortality in humans (HR 1.167, 95% CI 1.101–1.236).

    “showing the strongest association with CVD death (YCS: HR(95% CI) = 1.325 (1.060-1.656); JCS: HR(95% CI) = 1.167(1.101-1.236); P < 0.05)”

    HumansExternal validation in the Jurong Cohort Studyn = 16,652

    Association and predictive values of nine biological age measures for cardiovascular disease mortality: screening and validation from two prospective cohort studies

    GeroScience13 Sep 2025

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