Intrinsic capacity impairment

1. Intrinsic capacity impairment raises the risk of cardiovascular disease in humans (HR 1.33, 95% CI 1.12-1.58).

   “Compared with no IC decline, individuals with impairment in 2 or more domains had a significantly higher risk of incident CVD (CHARLS, HR=1.33, 95% CI: 1.12-1.58”

   Humansimpairment in 2 or more IC domains vs no IC decline

   Associations of Baseline and Changes in Intrinsic Capacity With Incident Cardiovascular Disease: A Multicohort Study

   Journal of the American Heart Association·Feb 3, 2026

More on Cardiovascular disease

1. Intrinsic capacity impairment raises the risk of mortality in humans (HR 2.14, 95% CI 1.10-4.15).

   “Men with impaired IC (hazard ratio [HR]; 2.14, 95% CI:1.10-4.15) and visual impairment (HR:2.21, 95% CI:1.15-4.25) and women with impaired psychological well-being (HR:4.94, 95% CI:1.28-18.97) in the NILS-LSA cohort had greater risk for all-cause mortality”

   Humansmalesn = 794

   Comparative Analysis of Intrinsic Capacity Impairments, Determinants, and Clinical Consequences in Older Community-Dwellers in Japan and Taiwan: Longitudinal Studies Showing Shared Traits and Distinct Presentations

   The journal of nutrition, health & aging·Jan 1, 2023

1. Intrinsic capacity impairment raises the risk of falls in humans (OR 1.50, 95% CI 1.03-2.20).

   “Male NILS-LSA participants with impaired IC (odds ratio [OR]:1.50, 95% confidence interval [CI]:1.03-2.20), with hearing loss (OR:1.98, 95% CI:1.00-3.90) were more likely to fall.”

   Humansmalesn = 794

   Comparative Analysis of Intrinsic Capacity Impairments, Determinants, and Clinical Consequences in Older Community-Dwellers in Japan and Taiwan: Longitudinal Studies Showing Shared Traits and Distinct Presentations

   The journal of nutrition, health & aging·Jan 1, 2023

1. Intrinsic capacity impairment raises the risk of IADL difficulty in humans (adjusted OR 3.3, 95%CI 1.8-6.1).

   “IADL difficulty (adjusted OR 3.3, 95%CI 1.8-6.1) compared with those without IC impairments”

   Humansimpairments in three or more domains vs without IC impairmentsone to three yearsn = 1,601

   Prevalence and Distribution of Intrinsic Capacity and Its Associations with Health Outcomes in Older People: The Jockey Club Community eHealth Care Project in Hong Kong

   The Journal of frailty & aging·Jan 1, 2022

1. Intrinsic capacity impairment raises the risk of poor/fair self-rated health in humans (adjusted OR 3.7, 95%CI 1.9-7.2).

   “poor/fair self-rated health (adjusted OR 3.7, 95%CI 1.9-7.2)”

   Humansimpairments in three or more domains vs without IC impairmentsone to three yearsn = 1,601

   Prevalence and Distribution of Intrinsic Capacity and Its Associations with Health Outcomes in Older People: The Jockey Club Community eHealth Care Project in Hong Kong

   The Journal of frailty & aging·Jan 1, 2022

1. Intrinsic capacity impairment raises the risk of urinary incontinence in humans (adjusted OR 3.0, 95%CI 1.8-5.0).

   “incontinence (adjusted OR 3.0, 95%CI 1.8-5.0)”

   Humansimpairments in three or more domains vs without IC impairmentsone to three yearsn = 1,601

   Prevalence and Distribution of Intrinsic Capacity and Its Associations with Health Outcomes in Older People: The Jockey Club Community eHealth Care Project in Hong Kong

   The Journal of frailty & aging·Jan 1, 2022

More on Urinary incontinence

1. Intrinsic capacity impairment raises the risk of polypharmacy in humans (adjusted OR 2.2, 95%CI 1.1-4.2).

   “those with impairments in three or more domains had the greatest risk for the incidence of polypharmacy (adjusted OR 2.2, 95%CI 1.1-4.2)”

   Humansimpairments in three or more domains vs without IC impairmentsone to three yearsn = 1,601

   Prevalence and Distribution of Intrinsic Capacity and Its Associations with Health Outcomes in Older People: The Jockey Club Community eHealth Care Project in Hong Kong

   The Journal of frailty & aging·Jan 1, 2022