There are 2 papers on intrarenal telomere length in aging research: 2 observational studies in people.
2 papers study it5 findings
“the specific mRNA expression of the molecules in the superpathway of cholesterol biosynthesis associated significantly with intrarenal telomere length”
- Humans2
Upstream
1Post-transplant events
no changein humans1
1 study
Post-transplant events
no changein humans1
post-transplant events were not clearly linked with intrarenal telomere length in humans.
“delayed graft function, acute rejection episodes, presence of donor-specific antibodies, cytomegalovirus disease and immunosuppressive regimen did not associate with alterations of intrarenal telomere length at 5 years”
Humanskidney5 years
Replicative senescence and arteriosclerosis after kidney transplantation
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Associations
3Arteriosclerosis
upin humans1downin humans1
2 studies
Arteriosclerosis
upin humans1downin humans1
Intrarenal telomere length is associated with arteriosclerosis in humans (independent of donor age and donor cardiovascular risk).
“intrarenal arteriosclerosis in protocol biopsies obtained at 5 years after transplantation and progressive arteriosclerosis over time after transplantation associated with shorter telomere length”
Humansindependent of donor age and donor cardiovascular riskkidney
Replicative senescence and arteriosclerosis after kidney transplantation
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Arteriosclerosis is associated with intrarenal telomere length in humans (test cohort, adjusted for history of cardiovascular events and calendar age) (T/S ratio 0.91±0.15 vs. 1.20±0.23 with vs. without arteriosclerosis, p=0.007).
“Shorter intrarenal telomere length associated significantly with the presence of renal arteriosclerosis”
Humanstest cohort, adjusted for history of cardiovascular events and calendar agekidneyn = 40
Aging
Donor age
downin humans1
1 study
Donor age
downin humans1
Donor age is associated with intrarenal telomere length in humans (at 5 years after transplantation).
“shorter intrarenal telomere length was associated with male donor gender, older donor age, donor history of hypertension and donor cardiovascular risk”
Humansat 5 years after transplantationkidney
Replicative senescence and arteriosclerosis after kidney transplantation
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
superpathway of cholesterol biosynthesis
mixedin humans1
1 study
superpathway of cholesterol biosynthesis
mixedin humans1
superpathway of cholesterol biosynthesis is associated with intrarenal telomere length in humans.
“the specific mRNA expression of the molecules in the superpathway of cholesterol biosynthesis associated significantly with intrarenal telomere length”
Humanskidney
Aging