1 paper3 findings
Time-restricted eating + exercise
no changein humans1
Time-restricted eating + exercise has no effect on intrahepatic fat fraction in humans (−1.1 percentage points versus usual care; 95% CI −2.7 to 0.5; P = 0.28).
“These findings do not support greater short-term IHFF reductions with TRE, exercise, or their combination than with UC or between intervention groups.”
Human trialObesity; compared with usual care consisting of Mediterranean diet and physical activity educationtime-restricted eating combined with supervised exerciseliver8-hour eating window12 weeks
Timed eating and exercise did not beat usual care for liver fat
Nature communications14 Oct 2026
Exercise
no changein humans1
Exercise has no effect on intrahepatic fat fraction in humans (−0.8 percentage points versus usual care; 95% CI −2.4 to 0.8; P = 0.54).
“These findings do not support greater short-term IHFF reductions with TRE, exercise, or their combination than with UC or between intervention groups.”
Human trialObesity; compared with usual care consisting of Mediterranean diet and physical activity educationsupervisedliver12 weeks
Timed eating and exercise did not beat usual care for liver fat
Nature communications14 Oct 2026
Time-restricted feeding
no changein humans1
Time-restricted feeding has no effect on intrahepatic fat fraction in humans (−0.4 percentage points versus usual care; 95% CI −2.0 to 1.2; P = 0.93).
“IHFF change did not differ with TRE (−0.4%; 95% CI, −2.0 to 1.2; P = 0.93)”
Human trialObesity; compared with usual care consisting of Mediterranean diet and physical activity educationliver8-hour eating window12 weeks
Timed eating and exercise did not beat usual care for liver fat
Nature communications14 Oct 2026
For timed eating, the 12-week liver fat change was 0.4 percentage points lower than with usual care; the range of likely values included no difference.For timed eating, the 12-week liver fat change was 0.4 percentage points lower than with usual care; the range of likely values included no difference.