IMMAX score

1. IMMAX score is associated with TCR Vd + Jd receptor diversity in humans (b = -0.02 in both control and exposed samples).

   “Higher immune age was also negatively correlated with TCR Vd + Jd receptor diversity regardless of immune challenge”

   HumansBoth vehicle-control and recombinant SARS-CoV-2 spike protein-exposed samplesperipheral blood mononuclear cell

   Immune age is correlated with decreased TCR clonal diversity and antibody response to SARS-CoV-2

   Scientific reports·6 Jun 2025

More on TCR Vd + Jd receptor diversity

1. IMMAX score is associated with IgG responsivity in humans (b = -0.01).

   “Immune age negatively correlated with IgG responsivity in older individuals with recent prior exposure to SARS-CoV-2 (b = -0.01; p = 0.05).”

   HumansRecent prior exposure to SARS-CoV-2peripheral blood mononuclear cell

   Immune age is correlated with decreased TCR clonal diversity and antibody response to SARS-CoV-2

   Scientific reports·6 Jun 2025

More on IgG responsivity

1. Chronological age is associated with IMMAX score in humans (0.75 versus 0.48).

   “individuals aged > 60 years demonstrated a higher immune 'age' as calculated by IMMAX score”

   Humansperipheral blood mononuclear celln = 49

   Immune age is correlated with decreased TCR clonal diversity and antibody response to SARS-CoV-2

   Scientific reports·6 Jun 2025