MedComm
Blocking a fat-derived signal dampened inflammation in cells
Experiments in five cell models tested leptin blockade, which reduced inflammatory responses in blood-vessel cells and some immune cells.Experiments in five cell models tested leptin blockade, which reduced inflammatory responses in blood-vessel cells and some immune cells.
Human cell studyInflammation
Who was studiedHuman cell-line-derived macrophages, 6 days
What changedBlocking leptin lowered inflammatory protein levels in macrophages compared with hyperglycemia alone
The catchInflammation was assessed through cytokine expression rather than functional immune responses