IGF-1R-positive cells

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Caloric restriction

downin mice1−33%

1 study

Caloric restriction decreases IGF-1R-positive cells in mice (-33%).
“In comparison, caloric-restricted mice show a 33% reduction in IGF-1R immunoreactive cells and a notable 24% decrease in the total cell population with aging.”
Animalsparaventricular nucleusfemales
Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience27 Dec 2006

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International Journal of Developmental Neuroscience27 Dec

Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice

Experiments in miceDietary restriction