IFN-gamma-secreting effector memory CD8+ T-cells

1 paper2 findings

Animals1

Interventions

2

Caloric restriction

downin mice1

1 study

Caloric restriction decreases IFN-gamma-secreting effector memory CD8+ T-cells in mice.
“inhibiting glycolysis using 2-deoxy-D-glucose or diet-based calorie restriction attenuated the increase in IFN-γ-secreting effector memory CD8+ T-cells”
Animalsin abacavir-treated B*57:01-Tg mice
Glycolytic metabolism of CD8⁺ T-cells affects susceptibility to human leukocyte antigen-mediated abacavir-induced hypersensitivity
British journal of pharmacology9 Apr 2026

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2-deoxy-d-glucose

downin mice1

1 study

2-deoxy-d-glucose decreases IFN-gamma-secreting effector memory CD8+ T-cells in mice.
“inhibiting glycolysis using 2-deoxy-D-glucose or diet-based calorie restriction attenuated the increase in IFN-γ-secreting effector memory CD8+ T-cells”
Animalsin abacavir-treated B*57:01-Tg mice
Glycolytic metabolism of CD8⁺ T-cells affects susceptibility to human leukocyte antigen-mediated abacavir-induced hypersensitivity
British journal of pharmacology9 Apr 2026

More on 2-deoxy-d-glucose

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British Journal of Pharmacology10 Apr

Glycolytic metabolism of CD8⁺ T-cells affects susceptibility to human leukocyte antigen-mediated abacavir-induced hypersensitivity

Experiments in miceBlood and immune system