i3C combined-risk z-score

1. Liver fat percentage is associated with i3C combined-risk z-score in humans (+0.07-unit per 1-unit %LF, p<0.01).

   “Each 1-unit increase in %LF was associated with an increase of 3% in Aix75, 0.1 m/s in PWV, and 0.07-unit in i3C score, adjusting for age, sex, Tanner stage and ancestry (all p<0.01).”

   Humansadjusting for age, sex, Tanner stage and ancestryn = 87

   Relationship of Liver Fat with Cardiovascular Risk in Youth of South Asian, White, and African American Ancestry: The CHARISMA Study

   ADA Scientific Sessions 2026 abstract·5 Jun 2026

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