HIV-1 intact proviral DNA

1. Gut-derived bacterial metabolites are associated with HIV-1 intact proviral DNA in humans.

   “Integration of these immunometabolic findings with HIV-1 reservoir measurements revealed that CD4+ T cell states defined by cell-associated GDBMs track with intact proviral DNA levels in vivo.”

   Humansin vivoCD4+ T cell

   Microbiome-derived metabolites shape CD4+ T cell differentiation and immune aging in HIV-1 infection

   JCI insight·21 Jul 2026

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